Exendin-4, a GLP-1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia-reperfusion injury.
Ruyi ZhaiHuan XuFangyuan HuJihong WuXiangmei KongXinghuai SunPublished in: British journal of pharmacology (2020)
Exendin-4 can restore injured microvascular patency in I/R. Exendin-4 may regulate retinal capillaries through the GLP-1 receptor-PI3K/Akt-eNOS/NO-cGMP pathway. Therefore, exendin-4 may be an effective treatment for improving tissue perfusion in I/R-related conditions.
Keyphrases
- pi k akt
- signaling pathway
- optical coherence tomography
- diabetic retinopathy
- cell proliferation
- cell cycle arrest
- nitric oxide
- acute myocardial infarction
- coronary artery disease
- endothelial cells
- heart failure
- computed tomography
- magnetic resonance imaging
- cerebral ischemia
- acute coronary syndrome
- nitric oxide synthase
- cell death
- magnetic resonance
- combination therapy
- atrial fibrillation
- protein kinase
- binding protein