Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation.

Lucas T HusquinMaxime RotivalMaud FagnyHélène QuachNora ZidaneLisa M McEwenJulia L MacIsaacMichael S KoborHugues AschardEtienne PatinLluis Quintana-Murci

Published in: Genome biology (2018)

Using a system-level approach, our study reveals substantial ancestry-related differences in DNA methylation and provides evidence for their causal impact on immune gene regulation.

Keyphrases

dna methylation
genome wide
gene expression
endothelial cells
drug induced
genome wide association study