Rapid Screening of High Priority N-Nitrosamines in Pharmaceutical, Forensic, and Environmental Samples with PSI-MS and FCSI-MS.
Trevor J McDanielJessica M HoltzEbenezer H BondzieMakoy OverfeltPatrick W FedickChristopher C MulliganPublished in: Rapid communications in mass spectrometry : RCM (2023)
PSI-MS and FCSI-MS were successful in detecting trace-level NAMS in complex liquid- and solid-phase matrices with little to no prior preparation. This work suggests that these methodologies can provide a means for assessing problematic pharmaceutical adulterants/degradants for expedited quality control, as well as enhancing environmental stewardship efforts and forensic investigations.