Metabonomic-Transcriptome Integration Analysis on Osteoarthritis and Rheumatoid Arthritis.
Ningyang GaoLi DingJian PangYuxin ZhengYuelong CaoHongsheng ZhanYinyu ShiPublished in: International journal of genomics (2020)
Genes such as HHAT, GYG1, and TRAF3, as well as metabolites including glucose, asparagine, and acetoacetate, might be implicated in the pathogenesis of OA and RA. Metabolites like ethanol and tyrosine might participate differentially in OA and RA progression via the gap junction pathway and phagosome pathway, respectively. TRAF3-acetoacetate interaction may be involved in regulating inflammation in OA and RA by the NF-kappa B and IL-17 pathway.
Keyphrases
- rheumatoid arthritis
- disease activity
- knee osteoarthritis
- ankylosing spondylitis
- ms ms
- oxidative stress
- interstitial lung disease
- genome wide
- nuclear factor
- gene expression
- signaling pathway
- type diabetes
- pi k akt
- metabolic syndrome
- lps induced
- blood pressure
- cell proliferation
- single cell
- skeletal muscle
- blood glucose
- immune response
- inflammatory response
- bioinformatics analysis
- weight loss