Exogenous 8-hydroxydeoxyguanosine ameliorates liver fibrosis through the inhibition of Rac1-NADPH oxidase signaling.

Seung Kak ShinKyung-Ok KimSe-Hee KimOh Sang KwonCheol Soo ChoiSung Hwan JeongYun Soo KimJu Hyun KimMyung-Hee Chung

Published in: Journal of gastroenterology and hepatology (2020)

Rac1 activation and NOX-derived ROS are implicated to liver fibrosis. The 8-OHdG ameliorates liver fibrosis through the inhibition of Rac1 activation and NOX-derived ROS.

Keyphrases

liver fibrosis
reactive oxygen species
cell death
dna damage
cell migration
mouse model
oxidative stress