Clinical Trials Increase Off-Study Drug Use: A Segmented Time-Series Analysis.

Guillaume Butler-Laporte Matthew Pellan ChengDaniel J G ThirionSamuel De L'Étoile-MorelCharles FrenetteKatryn PaquetteAlexander LawandiEmily G McDonaldTodd C Lee

Published in: Open forum infectious diseases (2020)

Despite the DASH trial being a negative study, it impacted the prescribing habits of local clinicians during recruitment. Trialists should be aware of potential off-target study effects, and prescribers should be wary of early uptake of interventions before definitive study results.

Keyphrases

clinical trial
primary care
physical activity
radiation therapy
climate change
study protocol
phase ii
drug induced