Exploring the Network between Adipocytokines and Inflammatory Response in SARS-CoV-2 Infection: A Scoping Review.
Ersilia NigroVito D'AgnanoGianluca QuarcioDomenica Francesca MarinielloAndrea BiancoAurora DanieleFabio PerrottaPublished in: Nutrients (2023)
Adipose tissue is actually regarded as an endocrine organ, rather than as an organ that merely stores energy. During the COVID-19 pandemic, obesity has undoubtedly emerged as one of the most important risk factors for disease severity and poor outcomes related to SARS-CoV-2 infection. The aberrant production of cytokine-like hormones, called adipokines, may contribute to alterations in metabolism, dysfunction in vascular endothelium and the creation of a state of general chronic inflammation. Moreover, chronic, low-grade inflammation linked to obesity predisposes the host to immunosuppression and excessive cytokine activation. In this respect, understanding the mechanisms that link obesity with the severity of SARS-CoV-2 infection could represent a real game changer in the development of new therapeutic strategies. Our review therefore examines the pathogenic mechanisms of SARS-CoV-2, the implications with visceral adipose tissue and the influences of the adipose tissue and its adipokines on the clinical behavior of COVID-19.
Keyphrases
- insulin resistance
- adipose tissue
- sars cov
- respiratory syndrome coronavirus
- low grade
- high fat diet induced
- high fat diet
- metabolic syndrome
- oxidative stress
- weight gain
- inflammatory response
- weight loss
- type diabetes
- coronavirus disease
- skeletal muscle
- high grade
- glycemic control
- body mass index
- physical activity
- toll like receptor
- immune response
- lps induced