The effect of cannabinoids on single-level lumbar arthrodesis outcomes in a rat model.

Harold FogelDiana YeritsyanKaveh MomenzadehNadim KheirCaleb M YeungMohammadreza AbbasianEdith Martinez LozanoRosalynn M NazarianAra Nazarian

Published in: The spine journal : official journal of the North American Spine Society (2024)

CBD and THC showed no inhibitory effects on bone healing in a spinal fusion model. Moreover, histologic and gene expression analysis demonstrated that CBD may, in fact, enhance bone healing. Further research is needed to confirm the safe usage of THC and CBD in the postoperative setting following spinal fusions.

Keyphrases

bone mineral density
spinal cord
genome wide identification
soft tissue
bone loss
bone regeneration
minimally invasive
patients undergoing
copy number
gene expression
type diabetes
transcription factor
genome wide analysis