Case report: recurrent pituitary adenoma has increased load of somatic variants.

Raitis PeculisInga BalcereIlze Radovica-SpalvinaIlze KonradeOlivija CauneKaspars MegnisVita RoviteJanis StukensJurijs NazarovsAustra BreiksaAigars KiecisIvars SilamikelisValdis PiragsJanis Klovins

Published in: BMC endocrine disorders (2020)

In this case study, an SNP located in HRAS is the most likely candidate inducing rapid PA progression. The relapsed PA tumour had a higher variation load and fast tumour recurrence in this patient could be caused by clonal expansion of the leftover tumour tissue.

Keyphrases

case report
copy number
acute lymphoblastic leukemia
acute myeloid leukemia
genome wide
multiple myeloma
diffuse large b cell lymphoma
hodgkin lymphoma
growth hormone
quantum dots
loop mediated isothermal amplification