White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease. Results from the ONDRI.
Daniela Cristina Carvalho de AbreuFrederico Pieruccini-FariaYanina Sarquis-AdamsonAlanna BlackJulia FraserKaren Van OoteghemBenjamin CornishDavid GrimesMandar JogMario MasellisThomas SteevesNuwan NanayakkaraJoel RamirezChristopher ScottMelissa HolmesMiracle OzzoudeCourtney BerezukSean SymonsSeyyed Mohammad Hassan HaddadStephen R ArnottMalcolm BinnsStephen StrotherDerek BeatonKelly SunderlandAthena TheyersBrian TanMojdeh ZamyadiBrian LevineJoseph B OrangeAngela C RobertsWendy LouSujeevini SujanthanDavid P BreenConnie MarrasDonna KwanSabrina AdamoAlicia PeltschAngela K TroyerSandra E BlackPaula M McLaughlinAnthony E LangWilliam McIlroyRobert Barthanull nullManuel Montero-OdassoPublished in: European journal of neurology (2023)
WMH burden at baseline predicted only cognitive decline in PD. The motor decline observed after 2-years in these participants with early to mid-stage PD is probably related to the primary neurodegenerative process more than comorbid WM pathology.