3D magnetic resonance spectroscopic imaging reveals links between brain metabolites and multidimensional pain features in fibromyalgia.
Jeungchan LeeOvidiu C AndronesiAngel Torrado-CarvajalEva-Maria RataiMarco L LoggiaAkila WeerasekeraMichael P BerryDan-Mikael EllingsenLaura IsaroAsimina LazaridouMyrella PaschaliArvina GrahlAjay D WasanRobert R EdwardsVitaly NapadowPublished in: European journal of pain (London, England) (2021)
This large N study linked brain metabolites and pain features in fibromyalgia patients, with a better spatial resolution and brain coverage, to understand a molecular mechanism underlying pain catastrophizing and other aspects of pain transmission. Metabolite levels in self-referential cognitive processing area as well as pain-processing regions were associated with pain outcomes. These results could help the understanding of its pathophysiology and treatment strategies for clinicians.
Keyphrases
- chronic pain
- pain management
- neuropathic pain
- magnetic resonance
- white matter
- ms ms
- spinal cord
- magnetic resonance imaging
- palliative care
- metabolic syndrome
- multiple sclerosis
- computed tomography
- mass spectrometry
- photodynamic therapy
- brain injury
- cerebral ischemia
- insulin resistance
- molecular docking
- functional connectivity