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Relationships between plasma biomarkers, tau PET, FDG PET, and volumetric MRI in mild to moderate Alzheimer's disease patients.

Dawn C MatthewsJefferson W KinneyAaron RitterRandolph D AndrewsErin N Toledano StromAna S LukicLauren N KoenigCarolyn RevtaHoward M FillitKate ZhongBabak TousiJames B LeverenzHoward H FeldmanJeffrey Cummings
Published in: Alzheimer's & dementia (New York, N. Y.) (2024)
Plasma pTau-181 and GFAP correlated with regional and global tau PET in mild to moderate AD.NfL correlated with FDG PET and cognitive endpoints but not plasma pTau-181 or tau PET.Volume and FDG PET showed strong relationships to tau PET, one another, and cognitive status.Temporal volumes most strongly predicted decline in both MMSE and ADAS-cog.Volume and plasma biomarkers can enrich for elevated tau PET with age a significant covariate.
Keyphrases
  • pet ct
  • positron emission tomography
  • pet imaging
  • computed tomography
  • cerebrospinal fluid
  • magnetic resonance imaging
  • newly diagnosed
  • ejection fraction