Targeted bisulfite sequencing of the dynamic DNA methylome.
Michael J ZillerElena K StamenovaHongcang GuAndreas GnirkeAlexander MeissnerPublished in: Epigenetics & chromatin (2016)
Our target capture design fills a major gap left by all other assays that exist to map DNA methylation. It maintains the ability to link cytosine methylation to genetic differences, the single-base resolution and the analysis of neighboring cytosines while notably reducing the cost per sample by focusing the sequencing effort on the most informative and relevant regions of the genome.