Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes.

Lucas MassierRima ChakarounShirin TabeiAlyce CraneKonrad David DidtJörg FallmannMartin von BergenSven-Bastiaan HaangeHenrike HeyneMichael StumvollMartin GerickeArne DietrichMatthias BlüherNiculina MusatPeter Kovacs

Published in: Gut (2020)

Our study provides contaminant aware evidence for the presence of bacteria and bacterial DNA in several ATs in obesity and T2D and suggests an important role of bacteria in initiating and sustaining local AT subclinical inflammation and therefore impacting metabolic sequelae of obesity.

Keyphrases

insulin resistance
type diabetes
adipose tissue
metabolic syndrome
weight loss
high fat diet induced
oxidative stress
weight gain
high fat diet
skeletal muscle
glycemic control
cardiovascular disease
cell free
single molecule
circulating tumor cells