Epimedium sagittatum Maxim ameliorates adriamycin-induced nephropathy by restraining inflammation and apoptosis via the PI3K/AKT signaling pathway.

Ru WangMengnan ZengBeibei ZhangQinqin ZhangShuangshuang XieYingbo HuRuyi FanMengya WangXiao YuYuhan ZhangXiao-Ke ZhengWeisheng Feng

Published in: Immunity, inflammation and disease (2023)

This study suggested that EPI ameliorates adriamycin-induced nephropathy by reducing inflammation and apoptosis through the PI3K/AKT signaling pathway, icariin may be the pharmacodynamic substance basis for this effect.

Keyphrases

oxidative stress
diabetic rats
signaling pathway
high glucose
pi k akt
cell cycle arrest
endoplasmic reticulum stress
induced apoptosis
cell death
mouse model
drug induced