Reversible effects on female rat fertility with abrocitinib, a Janus kinase 1 inhibitor.
Christopher J BowmanSarah N CampionNatasha R CatlinWilliam S NowlandChristine M StethemZaher A RadiGregg D CapponPublished in: Birth defects research (2024)
Based on these data and literature on the potential role of JAK signaling in implantation, we hypothesize that these effects may be related to JAK1 inhibition and, generally, that peri-implantation effects such as these, in the absence of cycling or microscopic changes in nonpregnant female reproductive tissues, are anticipated to be reversible.