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Direct Synthesis of Dipyrrolyldipyrrins from SNAr Reaction on 1,9-Dihalodipyrrins with Pyrroles and Their NIR Fluorescence "Turn-On" Response to Zn2.

Wei MiaoEn DaiWanle ShengChangjiang YuErhong HaoWanxiao LiuYun WeiLijuan Jiao
Published in: Organic letters (2017)
A set of dipyrrolyldipyrrins have been efficiently synthesized from a direct SNAr reaction on 1,9-dihalodipyrrins with pyrroles and show intense absorption in the NIR region (650-800 nm, as HCl salts). Substituents on both 1,9-dihalodipyrrins and pyrroles greatly affected the reactivity of this SNAr reaction and the absorption properties of the resultant dipyrrolyldipyrrins. These dipyrrolyldipyrrins show sensitive and selective "turn-on" fluorescence response toward Zn2+.
Keyphrases
  • fluorescent probe
  • photodynamic therapy
  • living cells
  • single molecule
  • heavy metals
  • sensitive detection
  • fluorescence imaging
  • drug release
  • electron transfer
  • risk assessment
  • drug delivery
  • quantum dots