Effect of age, sex, and morbidity count on trial attrition: meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials.

Jennifer Susan LeesPeter HanlonElaine W ButterlySarah H WildFrances S MairRod S TaylorBruce GuthrieKatie GilliesSofia DiasNicky J WeltonDavid A McAllister

Published in: BMJ medicine (2022)

Increased comorbidity count, irrespective of age and sex, is associated with a modest increased odds of participant attrition. The benefit of increased generalisability of including participants with multimorbidity seems likely to outweigh the disadvantages of increased attrition.

Keyphrases

clinical trial
study protocol
phase ii
electronic health record
machine learning
big data
open label