Cell Survival Failure in Effector T Cells From Patients With Systemic Lupus Erythematosus Following Insufficient Up-Regulation of Cold-Shock Y-Box Binding Protein 1.
Stefan MeltendorfHang FuMandy PierauJonathan A LindquistStephanie FinzelPeter R MertensSteffi Gieseler-HalbachAndreas AmbachUlrich ThomasHolger LingelReinhard E VollMonika C Brunner-WeinzierlPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Our data show that failure of YB-1 up-regulation in T cells from SLE patients led to enhanced apoptosis. These findings imply that YB-1 plays a crucial role in the disturbed homeostasis of activated T cells leading to hematopoietic alterations in SLE. These insights may help facilitate the development of new treatment strategies for SLE.
Keyphrases
- systemic lupus erythematosus
- binding protein
- disease activity
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- oxidative stress
- peritoneal dialysis
- bone marrow
- prognostic factors
- rheumatoid arthritis
- electronic health record
- cell death
- dendritic cells
- regulatory t cells
- energy transfer
- endoplasmic reticulum stress
- patient reported outcomes
- immune response
- cell cycle arrest
- big data
- signaling pathway
- quantum dots