Hyperleukocytosis is associated with distinct genetic alterations and is an independent poor-risk factor in de novo acute myeloid leukemia patients.

Feng-Ming TienHsin-An HouCheng-Hong TsaiJih-Luh TangChien-Yuan ChenYuan-Yeh KuoChi-Cheng LiChien-Ting LinMing YaoShang-Yi HuangBor-Sheng KoSzu-Chun HsuShang-Ju WuWoei TsayMei-Hsuan TsengMing-Chih LiuChia-Wen LiuLiang-In LinWen-Chien ChouHwei-Fang Tien

Published in: European journal of haematology (2018)

Hyperleukocytosis is an independent poor prognostic factor irrespective of cytogenetics and mutation status. Allo-HSCT in first CR seems to ameliorate the poor prognostic impact of HL.

Keyphrases

prognostic factors
acute myeloid leukemia
end stage renal disease
newly diagnosed
ejection fraction
risk factors
chronic kidney disease
dna methylation
patient reported outcomes
allogeneic hematopoietic stem cell transplantation