Melatonin inhibits Japanese encephalitis virus replication and neurotoxicity via calcineurin-autophagy pathways.

Ji-Hong MoonJeong-Min HongJae-Won SeolByung-Yong ParkSeong Kug EoSang-Youel Park

Published in: BMC neuroscience (2023)

Calcineurin inactivation has a protective effect in JEV-infected neuronal cells, and melatonin is a novel resource for the development of anti-JEV agents.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
cell cycle arrest
cell death
signaling pathway
oxidative stress
cerebral ischemia
pi k akt
blood brain barrier
disease virus