Microdissecting the Hypoxia Landscape in Colon Cancer Reveals Three Distinct Subtypes and Their Potential Mechanism to Facilitate the Development of Cancer.
Pingfei TangYueming WuChaojun ZhuQingyuan LiSi-de LiuPublished in: Journal of oncology (2023)
In our study, we discovered three hypoxia clusters which correlate with the clinical outcome and the tumor immune microenvironment in CC. Based on the hypoxia cluster and HRDEGs, we constructed a reliable HRI signature that could accurately predict the prognosis and immunotherapeutic responsiveness in CC patients and discovered four key genes that could affect tumor cell viability and apoptosis.
Keyphrases
- endothelial cells
- end stage renal disease
- ejection fraction
- newly diagnosed
- prognostic factors
- papillary thyroid
- cell death
- peritoneal dialysis
- genome wide
- single cell
- young adults
- cell proliferation
- risk assessment
- patient reported outcomes
- squamous cell
- lymph node metastasis
- patient reported
- genome wide identification