Epigenetic reshaping through damage: promoting cell fate transition by BrdU and IdU incorporation.

Chuang LiXiaoduo XuShuyan ChenAnchun XuTongxing GuanHaokaifeng WuDuanqing PeiJing Liu

Published in: Cell & bioscience (2024)

Overall, our study finds that BrdU/IdU can activate the DNA damage repair pathway (HRR), leading to increased histone acetylation and genome-wide DNA demethylation, regulating somatic cell reprogramming. This offers valuable insights into mechanisms underlying cell fate transition.

Keyphrases

cell fate
dna methylation
dna damage
genome wide
oxidative stress
gene expression
copy number
single cell
cell therapy
circulating tumor
dna repair
stem cells