Opportunities and challenges of implementing computed tomography fractional flow reserve into clinical practice.
Muhummad Sohaib NazirTarun K MittalJonathan Richard Weir-McCallKoen NiemanKeith ChannonEdward D NicolPublished in: Heart (British Cardiac Society) (2020)
CT-derived fractional flow reserve (CT-FFR) uses computational fluid dynamics to derive non-invasive FFR to determine the haemodynamic significance of coronary artery lesions. Studies have demonstrated good diagnostic accuracy of CT-FFR and reassuring short-term clinical outcome data.As a prerequisite, high-quality CT coronary angiography (CTCA) images are required with good heart rate control and pre-treatment with glyceryl trinitrate, which would otherwise render CTCA as unsuitable for CT-FFR. CT-FFR can determine the functional significance of CAD lesions, and there are supportive data for its use in clinical decision-making. However, the downstream impact on myocardial ischaemic burden or viability cannot be obtained.Several challenges remain with implementation of CT-FFR, including interpretation, training, availability, resource utilisation and funding. Further research is required to determine which cases should be considered for clinical CT-FFR analysis, with additional practical guidance on how to implement this emerging technique in clinical practice. Furthermore, long-term prognostic data are required before widespread clinical implementation of CT-FFR can be recommended.While there are several potential opportunities for CT-FFR, at present there remain important systemic and technical limitations and challenges that need to be overcome prior to routine integration of CT-FFR into clinical practice.
Keyphrases
- computed tomography
- dual energy
- image quality
- contrast enhanced
- positron emission tomography
- clinical practice
- coronary artery
- heart rate
- magnetic resonance imaging
- magnetic resonance
- blood pressure
- electronic health record
- deep learning
- pulmonary artery
- machine learning
- optical coherence tomography
- climate change
- pulmonary hypertension
- left ventricular
- pet ct
- pulmonary arterial hypertension