Grking the Smoothened signal.

The kinase GRK2 has been linked to the clinically important Hedgehog (HH) signaling pathway, where it is paradoxically required for signal transduction yet also promotes internalization and degradation of the critical HH signal transducer Smoothened. Two reports by Li et al and Pusapati et al in this issue of Science Signaling provide new insights into the role of GRK2 in HH signaling.