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Prior EGFR-TKI Treatment in EGFR-Mutated NSCLC Affects the Allele Frequency Fraction of Acquired T790M and the Subsequent Efficacy of Osimertinib.

Allen Chung-Cheng HuangChi-Hsien HuangChien-Ying LiuStelios PavlidisHo-Wen KoFu-Tsai ChungTin-Yu LinChih-Liang WangYi-Ke GuoCheng-Ta Yang
Published in: Targeted oncology (2020)
Acquired T790M fraction of EGFR-mutated NSCLC is linked to different generations of prior EGFR TKI use and the later efficacy of osimertinib.
Keyphrases
  • small cell lung cancer
  • epidermal growth factor receptor
  • advanced non small cell lung cancer
  • tyrosine kinase
  • brain metastases
  • smoking cessation