Cumulative tenofovir diphosphate exposure in persons with HIV taking single- vs. multiple-tablet regimens.

Ryan P CoyleMary MorrowSamantha MaWhinneyStacey S ColemanJia-Hua ZhengLucas EllisonLane R BushmanJennifer J KiserPeter L AndersonJose R Castillo-Mancilla

Published in: Pharmacotherapy (2022)

Persons with HIV on b/TDF-based ART had higher TFV-DP than u/ART, regardless of STR or MTR use. No significant differences in TFV-DP between regimens of the same boosting status (i.e., b/STR vs. b/MTR; u/STR vs. u/MTR) were observed in the full cohort. Future research should examine the clinical utility of these findings in patient-tailored ART selection.

Keyphrases

antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
hiv aids
case report
hiv testing
hepatitis c virus
current status