CNS Antigen-Specific Neuroinflammation Attenuates Ischemic Stroke With Involvement of Polarized Myeloid Cells.
Kirsten GuseNina HagemannLisa ThieleJana RemlingerSalmen AnkeRobert HoepnerIrene KellerPatricia MeyerDenis GrandgirardStephen L LeibErik VassellaGiuseppe LocatelliDirk M HermannAndrew ChanPublished in: Neurology(R) neuroimmunology & neuroinflammation (2022)
CNS autoantigen-specific autoimmunity has a protective influence on primary tissue damage after experimental stroke, indicating a very early involvement of CNS antigen-specific, myeloid cell-associated anti-inflammatory immune mechanisms that mitigate ischemic injury in the acute EAE phase.
Keyphrases
- blood brain barrier
- cerebral ischemia
- atrial fibrillation
- anti inflammatory
- induced apoptosis
- dendritic cells
- bone marrow
- acute myeloid leukemia
- liver failure
- cell cycle arrest
- oxidative stress
- traumatic brain injury
- cell therapy
- respiratory failure
- drug induced
- lipopolysaccharide induced
- lps induced
- cognitive impairment
- stem cells
- ischemia reperfusion injury
- cell death
- endoplasmic reticulum stress
- mesenchymal stem cells
- signaling pathway
- cell proliferation