NUDT15 c.415C>T Polymorphism Predicts 6-MP Induced Early Myelotoxicity in Patients with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy.

Aswin Anand PaiAjith MohanEsther Sathya Bama BenjaminRaveen Stephen Stallon IllangeswaranInfencia Xavier RajNancy Beryl JanetArun Kumar ArunachalamM L KavithaUday KulkarniAnup J DevasiaN A FouziaAby AbrahamAlok SrivastavaBiju GeorgeVikram MathewsAnu KorulaPoonkuzhali Balasubramanian

Published in: Pharmacogenomics and personalized medicine (2021)

NUDT15 c.415 C>T (15*3), TPMT*3C, as well as ITPA c.94 C>A and MRP4 c.2269 C>T polymorphisms explain hematotoxicities. Preemptive genotype-based (NUDT15*3, TPMT, ITPA c.94 C>A) 6-MP dosing could improve the outcome after maintenance therapy.

Keyphrases

acute lymphoblastic leukemia
high glucose
diabetic rats
stem cells
oxidative stress
mesenchymal stem cells
smoking cessation