Early predictors of disability in paediatric multiple sclerosis: evidence from a multi-national registry.
Sifat SharminCharles B MalpasIzanne RoosIbrahima DioufRaed AlroughaniSerkan OzakbasGuillermo IzquierdoSara EichauDana HorakovaEva K HavrdovaFrancesco PattiMurat TerziCavit BozBassem YamoutSamia Joseph KhouryMarco OnofrjAlessandra LugaresiAyse AltintasAlexandre PratMarc GirardPierre DuquetteMaria José SáDaniele La SpitaleriYoussef SidhomRiadh GoudierSaloua MrabetAysun SoysalRecai TurkogluMaria Pia AmatoYara D FragosoTomas KalincikPublished in: Journal of neurology, neurosurgery, and psychiatry (2022)
A relatively later onset of MS in childhood, higher disability and pyramidal, visual or cerebellar symptoms during the first year predicted significant worsening in disability in patients with paediatric-onset MS. Persistent treatment with higher-efficacy DMTs was associated with a reduced rate of disability worsening.