USP30: protector of peroxisomes and mitochondria.
Victoria RiccioG Angus McQuibbanPeter Kijun KimPublished in: Molecular & cellular oncology (2019)
In our recent publication, we describe a mechanism by which peroxisomes are protected from degradation by autophagy under basal conditions. Taking a page from mitophagy, peroxisomes also recruit the mitochondria deubiquitinating enzyme USP30 to counter the action of PEX2, the peroxisomal E3 ubiquitin ligase to regulate pexophagy.