Biomarker concordance between primary colorectal cancer and ovarian metastases: a Dutch cohort study.
Richard van der MeerJudith W M JeukenSteven L BoschFelice N van ErningLieke H J SimkensIgnace H J T de HinghRudi M H RoumenPublished in: Journal of cancer research and clinical oncology (2022)
Complete biomarker concordance was found between MMR proficient CRC and their matching ovarian metastasis. Biomarker testing of MMR proficient CRC tissue appears to be sufficient, and additional testing of metastatic ovarian tissue is not necessary. Differences in therapy response between ovarian metastases and other metastases from CRC are thus unlikely to be caused by differences in the genetic status.