Expert Consensus on the Management of Adverse Events of Lorlatinib in the Treatment of ALK+ Advanced Non-small Cell Lung Cancer.
Edurne ArriolaJavier de CastroRosario García-CampeloBeatriz BernárdezReyes BernabéJordi BrunaManuel DómineDolores IslaÓscar Juan-VidalTeresa López-FernándezErnest NadalDelvys Rodríguez-AbreuMaría VaresÚrsula AsensioLuis F GarcíaEnriqueta FelipPublished in: Clinical drug investigation (2024)
The use of anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs), such as lorlatinib, for the treatment of patients with ALK gene rearrangement (or ALK-positive) non-small cell lung cancer (NSCLC) has been shown to improve the overall survival and quality of life of these patients. However, lorlatinib is not exempt from potential adverse events. Adequate monitoring and management of these adverse events are critical for increasing patient adherence to lorlatinib, thereby maximizing the benefits of treatment and minimizing the risks associated with treatment discontinuation. Considering that the adverse events of lorlatinib can affect different organs and systems, the participation of a multidisciplinary team, including cardiologists, neurologists, internal medicine specialists, and oncology pharmacists, is needed. This article presents specific and pragmatic strategies for identifying and treating the most relevant adverse events associated with lorlatinib in patients with advanced ALK-positive NSCLC based on the clinical experience of a multidisciplinary panel of experts.
Keyphrases
- advanced non small cell lung cancer
- epidermal growth factor receptor
- small cell lung cancer
- end stage renal disease
- gene expression
- palliative care
- risk assessment
- chronic kidney disease
- metabolic syndrome
- skeletal muscle
- diffuse large b cell lymphoma
- case report
- genome wide
- quality improvement
- transcription factor
- replacement therapy
- smoking cessation
- brain metastases
- double blind