Staphylococcus aureus infected embolic stroke upregulates Orm1 and Cxcl2 in a rat model of septic stroke pathology.
Lærke Boye AstrupKerstin SkovgaardRune Skovgaard RasmussenTine Moesgaard IburgJoergen Steen AgerholmBent AalbækHenrik Elvang JensenOle Lerberg NielsenFlemming Fryd JohansenPeter Mikael Helweg HeegaardPáll Skúli LeifssonPublished in: Neurological research (2019)
Septic embolic stroke caused brain abscesses, increased mortality and upregulated Orm1 and Cxcl2 gene expressions compared to non-infected embolic stroke. The dramatic Orm1 increase observed in the septic group is unprecedented and suggests a significant biological role of Orm1 during septic neuroinflammation.
Keyphrases
- atrial fibrillation
- acute kidney injury
- cerebral ischemia
- staphylococcus aureus
- traumatic brain injury
- type diabetes
- cardiovascular disease
- subarachnoid hemorrhage
- transcription factor
- brain injury
- copy number
- lipopolysaccharide induced
- blood brain barrier
- pseudomonas aeruginosa
- methicillin resistant staphylococcus aureus