Predictive Accuracy of a Clinical and Genetic Risk Model for Atrial Fibrillation.

Shaan Khurshid Qiuxi HuangLu-Chen WengDustin N Hartzelnull nullKathryn L Lunetta Jeffrey M Ashburner Christopher D Anderson Emelia J Benjamin Veikko V Salomaa Patrick T Ellinor Ludovic Trinquart Steven A Lubitz

Published in: Circulation. Genomic and precision medicine (2021)

AF risk estimation using clinical factors may prioritize individuals for AF screening more precisely than the age threshold endorsed in current guidelines. The additional value of genetic predisposition is modest but greatest among younger individuals.

Keyphrases

atrial fibrillation
genome wide
heart failure
catheter ablation
copy number
oral anticoagulants
left atrial appendage
direct oral anticoagulants
gene expression
clinical practice