COQ8B nephropathy: Early detection and optimal treatment.
Xiaoxiang SongXiaoyan FangXiaoshan TangQi CaoYihui ZhaiJing ChenJialu LiuZhiqing ZhangTianchao XiangYanyan QianBingbing WuHuijun WangWen-Hao ZhouCuihua LiuQian ShenHong XuJia RaoPublished in: Molecular genetics & genomic medicine (2020)
COQ8B mutations are one of the most common causes of adolescent-onset proteinuria and/or CKD of unknown etiology in the Chinese children. Early detection of COQ8B nephropathy following CoQ10 supplementation combined with ACE inhibitor could slow the progression of renal dysfunction. Renal transplantation in patients with COQ8B nephropathy showed no recurrence of proteinuria.