A facile and efficient method for the synthesis of crystalline tetrahydro-β-carbolines via the Pictet-Spengler reaction in water.
Hong-Ju ByeonKyung-Hwan JungGi-Seong MoonSung-Kwon MoonHyang-Yeol LeePublished in: Scientific reports (2020)
A facile and efficient synthesis of tetrahydro-β-carbolines (tryptolines) in one step from tryptamine and aldehydes, in an environmentally friendly water solvent, has been investigated. This convenient and clean synthesis of various tryptolines was facilitated by L-tartaric acid, a natural compound, to obtain the desired products as clear crystals. Among the four crystalline products, the most substituted tryptoline 2 showed the best inhibitory activity against EJ cells and the least cytotoxicity, with an LC50 value of 1.49 mg/mL, against brine shrimp larvae.
Keyphrases
- room temperature
- induced apoptosis
- quantum dots
- cell cycle arrest
- highly efficient
- reduced graphene oxide
- ionic liquid
- mass spectrometry
- molecular docking
- gold nanoparticles
- metal organic framework
- atomic force microscopy
- signaling pathway
- endoplasmic reticulum stress
- aedes aegypti
- single molecule
- cell proliferation