Mechanisms of Cytotoxicity of Chemical Agents to Giant Cell Tumors: An In Vitro Study.

Achmad Fauzi KamalAkbar Rizki Beni AsdiAhmad Jabir Rahyussalim Rio WikanjayaResda Akhra SyahraniTri KurniawatiSeptelia Inawati Wanandi

Published in: Stem cells international (2020)

Administering local chemical adjuvants of H2O2 in vitro caused loss of viable GCT cells. The number of viable cells after H2O2 exposure was related to the concentration-dependent effect, whereas reducing concentration of H2O2 may cause loss of viability and morphology of cultured GCT cells with the apoptotic mechanism.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
endoplasmic reticulum stress
oxidative stress
signaling pathway
endothelial cells
anti inflammatory