The Effect of Canertinib on Sensitivity of Cytotoxic Drugs in Tamoxifen-Resistant Breast Cancer Cells In Vitro.

Hesham A M GomaaAsmaa T Ali Mohamed Abdel GabbarM A Kandeil

Published in: International journal of genomics (2018)

Proliferation inhibition and apoptosis in MCF-7/TAM-R cells increase with increasing dosage of canertinib. This suggests that canertinib can reverse tamoxifen resistance in breast cancer cells. The antitumor effect of this EGFR-irreversible tyrosine kinase inhibitor provides a rationale for its clinical evaluation in combination with other cytotoxic drugs.

Keyphrases

breast cancer cells
cell cycle arrest
clinical evaluation
induced apoptosis
cell death
endoplasmic reticulum stress
small cell lung cancer
pi k akt
signaling pathway
oxidative stress
epidermal growth factor receptor
tyrosine kinase