Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.
Jonas SkogestadIngrid AlbertKarina HougenGustav B LotheMarianne LundeOlav Søvik EkenIoanni VerasNgoc Trang Thi-HuynhMira BørstadSerena MarshallXin ShenWilliam Edward LouchEmma Louise RobinsonJoseph C ClevelandAmrut V AmbardekarJessica A SchwisowEric JonasAna Isabel Costa CalejoJens Preben MorthKjetil TaskénArne Olav MellebyPer Kristian LundeIvar SjaastadCathrine Rein CarlsonJan Magnus AronsenPublished in: Circulation (2023)
Our results suggest that PDE3A regulates SERCA2 activity through direct binding, independently of the catalytic activity of PDE3A. Targeting the SERCA2/PDE3A interaction prevented cardiac mortality after aortic banding, most likely by improving cardiac contractility.