Phlebotomy-induced anemia alters hippocampal neurochemistry in neonatal mice.
Diana J WallinIvan TkacSara StuckerKathleen M EnnisMartha Sola-VisnerRaghavendra RaoMichael K GeorgieffPublished in: Pediatric research (2015)
This clinically relevant model of neonatal anemia alters hippocampal energy and phospholipid metabolism and gene expression during a critical developmental period. Low target hematocrits for preterm neonates in the neonatal intensive care unit (NICU) may have potential adverse neural implications.
Keyphrases
- preterm infants
- low birth weight
- gene expression
- iron deficiency
- chronic kidney disease
- high glucose
- cerebral ischemia
- dna methylation
- preterm birth
- diabetic rats
- temporal lobe epilepsy
- high fat diet induced
- drug induced
- emergency department
- metabolic syndrome
- gestational age
- type diabetes
- oxidative stress
- endothelial cells
- brain injury
- stress induced