Lnc-RP11-536 K7.3/SOX2/HIF-1α signaling axis regulates oxaliplatin resistance in patient-derived colorectal cancer organoids.

Qingguo LiHuizhen SunDakui LuoLu GanShaobo MoWeixing DaiLei LiangYufei YangMidie XuJing LiPeiyong ZhengXinxiang LiYan LiZiliang Wang

Published in: Journal of experimental & clinical cancer research : CR (2021)

In conclusion, our findings indicated that lnc-RP11-536 K7.3 could promote proliferation, glycolysis, angiogenesis, and chemo-resistance in CC by SOX2/USP7/HIF-1α signaling axis. This revealed a new insight into how lncRNA could regulate chemosensitivity and provide a potential therapeutic target for reversing resistance to oxaliplatin in the management of CC.

Keyphrases

endothelial cells
stem cells
transcription factor
signaling pathway
photodynamic therapy
long non coding rna
vascular endothelial growth factor
radiation therapy
human health
climate change