Lung Fibrosis Is Improved by Extracellular Vesicles from IFNγ-Primed Mesenchymal Stromal Cells in Murine Systemic Sclerosis.

Pauline RozierMarie MaumusAlexandre Thibault Jacques MariaKarine ToupetChristian JorgensenPhilippe Guilpain Danièle Noël

Published in: Cells (2021)

IFNγ-pre-activation improved the therapeutic effect of MSC-EVs preferentially in the lungs of SSc mice by modulating anti-inflammatory and anti-fibrotic markers.

Keyphrases

systemic sclerosis
interstitial lung disease
anti inflammatory
dendritic cells
immune response
bone marrow
signaling pathway
high fat diet induced
metabolic syndrome
idiopathic pulmonary fibrosis
insulin resistance
wild type