miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.

Brooke RheadXiaorong ShaoJennifer S GravesTanuja ChitnisAmy T WaldmanTimothy LotzeTeri SchreinerAnita BelmanLauren KruppBenjamin M GreenbergBianca Weinstock-GuttmanGregory AaenJan M TillemaMoses RodriguezJanace HartStacy CaillierJayne NessYolanda HarrisJennifer RubinMeghan S CandeeMark GormanLeslie BensonSoe MarIlana KahnJohn RoseT Charles CasperHong QuachDiana QuachCatherine SchaeferEmmanuelle WaubantLisa F Barcellosnull null

Published in: Annals of clinical and translational neurology (2019)

Evidence from GWAS suggests that miRNAs play a role in ped-MS pathogenesis by affecting immune signaling and other pathways. Candidate biomarker miRNA-target gene pairs should be further studied for diagnostic, prognostic, and/or therapeutic utility.

Keyphrases

multiple sclerosis
mass spectrometry
white matter
genome wide
copy number
ms ms
transcription factor
childhood cancer