Low frequency optogenetic deep brain stimulation of nucleus accumbens dopamine D1 or D2 receptor-containing neurons attenuates cocaine seeking selectively in male rats in part by reversing synaptic plasticity deficits.
Sarah E Swinford-JacksonMatthew T RichPhillip J HuffmanMelissa C KnouseArthur S ThomasSharvari MankameSamantha J WorobeyR Christopher PiercePublished in: bioRxiv : the preprint server for biology (2023)
These results suggest that administering DBS in the nucleus accumbens shell at lower frequencies effectively, but sex-specifically, suppresses cocaine craving, perhaps in part by reversing synaptic plasticity deficits selectively in D2DR-MSNs.