Dysregulation of circulating collagen turnover markers in very early systemic sclerosis.
Rucsandra DobrotaSuzana JordanPernille JuhlNicoletta Del PapaBritta MaurerMike BeckerCarmen-Marina MihaiAnne-C Bay-JensenMorten Asser KarsdalAnne Sofie SiebuhrOliver DistlerPublished in: RMD open (2024)
These findings indicate ECM remodelling as a very early phenomenon of SSc occurring in parallel with microvascular and autoimmune changes. Biomarkers of type III and IV collagens distinguished between veSSc patients and HC, indicating them as potential biomarkers for the detection of veSSc.
Keyphrases
- systemic sclerosis
- type iii
- interstitial lung disease
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- multiple sclerosis
- peritoneal dialysis
- prognostic factors
- rheumatoid arthritis
- patient reported outcomes
- loop mediated isothermal amplification
- label free
- patient reported
- postmenopausal women
- wound healing