A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum.

Marcele F BastosLetusa AlbrechtAngélica M GomesStefanie Cp LopesCristina P VicenteRodrigo Pm de AlmeidaGustavo C CassianoRoberto Jc FonsecaClaudio C WerneckMauro Sg PavãoFabio Trindade Maranhão Costa

Published in: Memorias do Instituto Oswaldo Cruz (2019)

These findings support a potential use for mollusk HS as adjunct therapy for severe malaria.

Keyphrases

plasmodium falciparum
cell migration
early onset
human health
risk assessment
drug induced