Aberrant RNA Splicing Is a Primary Link between Genetic Variation and Pancreatic Cancer Risk.

Jian-Bo TianCan ChenMeilin RaoMing ZhangZequn LuYimin CaiPingting YingBin LiHaoxue WangLu WangYao LiJinyu HuangLinyun FanXiaomin CaiCaibo NingYanmin LiFuwei ZhangWenzhuo WangYuan JiangYizhuo LiuMin WangHeng LiChaoqun HuangZhiyong YangJiang ChangYing ZhuXiaojun YangXiaoping Miao

Published in: Cancer research (2022)

In pancreatic cancer, splicing quantitative trait loci analysis identifies a rs1785932 variant that contributes to decreased risk of disease by influencing ELP2 mRNA splicing and blocking the STAT3 oncogenic pathway.

Keyphrases

genome wide
dna methylation
cell proliferation
transcription factor
high resolution
gene expression
binding protein
mass spectrometry