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Endothelial nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome regulation in atherosclerosis.

Shuai GuoLitao WangKaixiang CaoZiling LiMingchuan SongShuqi HuangZou LiCailing WangPeiling ChenYong WangXiaoyan DaiXianglin ChenXiaodong FuDu FengJun HeYuqing HuoYiming Xu
Published in: Cardiovascular research (2024)
Our findings highlight the existence of a glycolysis-dependent NADH/CtBP/FOXP1-transrepression pathway that regulates endothelial NLRP3 inflammasome activation in atherogenesis. This pathway represents a potential target for selective PFKFB3 inhibitors or strategies aimed at disrupting CtBP1 oligomerization to modulate atherosclerosis.
Keyphrases
  • nlrp inflammasome
  • cardiovascular disease
  • endothelial cells
  • binding protein
  • protein protein
  • amino acid
  • immune response
  • transcription factor