Remote Ischemic Perconditioning Ameliorates Myocardial Ischemia and Reperfusion-Induced Coronary Endothelial Dysfunction and Aortic Stiffness in Rats.
Petra Lujza SzabóChristopher DostalPatrick Michael PilzOuafa HamzaEylem AcarSimon WatzingerShalett MathewGerd KagerSeth HallströmBruno Karl PodesserAttila KissPublished in: Journal of cardiovascular pharmacology and therapeutics (2021)
Our study for the first time demonstrated that RIPerc alleviates MIR-induced coronary artery endothelial dysfunction in non-occluded artery segments and attenuates aortic stiffness in rats. The vascular protective effects of RIPerc are associated with ameliorated inflammation and might therefore be caused by reduced inflammatory signaling.
Keyphrases
- coronary artery
- pulmonary artery
- oxidative stress
- left ventricular
- diabetic rats
- high glucose
- aortic valve
- coronary artery disease
- drug induced
- acute myocardial infarction
- cerebral ischemia
- heart failure
- ischemia reperfusion injury
- percutaneous coronary intervention
- long noncoding rna
- brain injury
- acute coronary syndrome
- ejection fraction